A recent study published in NPJ Metabolic Health and Disease suggests that the degradation of endogenously secreted insulin, termed ‘chain-splitting,’ is a key mechanism underlying insulin resistance. The study challenges the commonly held belief that insulin receptor signaling defects are responsible for insulin resistance. Researchers demonstrate that chain-splitting of human insulin chains A and B occurs during transit in the bloodstream, leading to reduced insulin availability at target cells and contributing to insulin resistance. This novel hypothesis suggests that manipulating redox states in the plasma environment through factors like diet and exercise could offer new avenues for treating insulin resistance and associated conditions.
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Insulin degradation uncovered as a new driver of resistance
