A study by Johns Hopkins Medicine reveals that people aged 60 or older with weakened immunity, such as organ transplant recipients on immunosuppressive medications, have a reduced response to vaccines against respiratory syncytial virus (RSV) compared to those with normal immune function. The research, published in JAMA, aimed to understand vaccine responses in immunocompromised individuals, like those at risk for serious RSV infections. The study found that vaccines with adjuvants tended to produce higher levels of antibodies, suggesting potential enhancements in immune response. This information could guide vaccine selection and timing for immunocompromised populations, improving protection against RSV.
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