Researchers have developed a technique to improve cell transplantation therapy for stroke or traumatic brain injury by using human induced pluripotent stem cell-derived brain organoids. The study, published in Stem Cells Translational Medicine, found that treatment with the growth factor progranulin enhanced the survival and engraftment of transplanted neurons. This priming agent improved axonal extension and engraftment efficiency, potentially offering a new approach to repairing damaged neural circuits and promoting motor function recovery. Further research is needed to determine optimal administration routes and assess safety implications, such as tumor formation, to ensure more effective and safer cell transplantation therapies.
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Enhancing the efficacy of cell transplantation therapy for stroke or traumatic brain injury
