Fragmented sleep, characterized by increased wakefulness and reduced sleep efficiency, is linked to metabolic dysfunction-associated steatotic liver disease (MASLD). Researchers used actigraphy to assess sleep-wake rhythms in 35 MASLD patients and 16 healthy controls. Patients with MASLD showed more wakefulness at night, longer time spent awake after falling asleep, and decreased sleep efficiency compared to controls. Subgroup analyses found similar impairments in patients with different liver disease subtypes. Patients reported shorter, delayed sleep with stress-related disturbances. Sleep education did not improve sleep parameters. The study suggests that sleep fragmentation may play a role in the pathogenesis of MASLD.
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Broken Sleep Linked to MASLD
