Scientists at Scripps Research discovered the interactions between polyphosphate (polyP), DNA, and magnesium, forming structures called condensates. This interaction could impact cellular responses and has applications in translational medicine. The study, published in Nature Communications, reveals that DNA wraps around polyP-magnesium ion condensates in a specific magnesium concentration range. This DNA shell affects molecule transportation and fusion of condensates. The research team used cryo-electron tomography to examine condensate surfaces and discovered that DNA forms filaments protruding from the surfaces. This discovery could lead to new tools for cellular control and the development of cost-effective approaches in biomedicine.
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A key to cellular adaptability and resilience
