Researchers have identified the redox protein peroxiredoxin 6 (PRDX6) as a critical regulator of ferroptosis, a form of oxidative cell death with potential therapeutic applications in cancer and neurodegenerative diseases. PRDX6 acts as a selenium carrier protein, impacting cellular defense against oxidative stress and sensitizing cancer cells to ferroptosis while potentially protecting neurons from neurodegenerative diseases. The study, led by Dr. Eikan Mishima, reveals that PRDX6 deficiency reduces tumor growth and selenoprotein levels in the brain, highlighting its importance in cancer biology and brain health. Targeting PRDX6 could lead to new anti-cancer and neurodegenerative disease therapies.
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Specific redox protein identified as a critical regulator of ferroptosis
