Researchers have identified ceramide synthase 5 and 6 enzymes as crucial in how saturated fats worsen multiple sclerosis symptoms. These enzymes are responsible for the synthesis of the sphingolipid ceramide C16 from palmitic acid, contributing to the severity of neurodegenerative diseases like multiple sclerosis. By inhibiting these enzymes in murine models, researchers found reduced disease severity and delayed onset, especially when high-fat diets were avoided. Targeting these enzymes could be a potential therapeutic strategy for multiple sclerosis patients, along with dietary modifications to limit sources of palmitic acid. Additionally, the study highlighted the impact of ceramide C16 accumulation on mitochondrial function in neurons.
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Saturated fats accelerate neurodegeneration in multiple sclerosis
