Researchers have discovered that the SARS-CoV-2 spike protein can persist in the brain’s protective layers and skull bone marrow for up to four years after infection, leading to chronic inflammation and potentially increasing the risk of neurodegenerative diseases. The study, published in Cell Host & Microbe, also found that mRNA COVID-19 vaccines can reduce the accumulation of spike protein in the brain, although not completely. The findings highlight the need for additional therapies to address the long-term effects of COVID-19, especially in individuals with long COVID. This research offers new possibilities for diagnosing and treating the neurological impacts of COVID-19.
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SARS-CoV-2 spike protein accumulation linked to long-lasting brain effects
