A recent study published in Nature Cardiovascular Research reveals the role of the RNA-modifying enzyme Mettl1 in heart cell maturation after birth. The study highlights the importance of ketogenesis in driving the transition from glucose to fatty acids for metabolism in heart cells. Mettl1 regulates the expression of genes essential for fatty acid oxidation and oxidative phosphorylation, impacting sarcomere structure, mitochondrial function, and ATP levels. Loss of Mettl1 activity leads to metabolic imbalances, suggesting that targeting Mettl1 or ketogenesis could offer potential treatments for metabolic and developmental heart disorders. Further research is needed to fully understand the mechanisms involved.
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RNA enzyme found key to heart cell energy shift after birth
