A specialized diet free of serine and glycine enhances immune cell activity and improves the effectiveness of immunotherapy in colorectal cancer patients. The study explores the impact of the diet on tumor growth and the tumor microenvironment, focusing on cell-mediated antitumor immunity. The diet inhibits tumor growth by promoting T cell responses to tumor neoantigens, but also induces immune evasion by increasing PD-L1 levels in tumor cells. The diet was found to be safe in a phase 1 clinical trial and could potentially be used in conjunction with immunotherapy for colorectal cancer treatment. Further research is needed to validate these findings and explore new therapeutic strategies for solid tumors.
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Phase 1 study finds serine- and glycine-free diet boosts immune response in colorectal cancer
