Novel Intervention Slows Cognitive Decline in At-Risk Adults

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Combining cognitive remediation (CR) with transcranial direct current stimulation (tDCS) in older adults with major depressive disorder (MDD) in remission, mild cognitive impairment (MCI), or both can slow cognitive decline for up to 6 years. The CR intervention involved mental exercises to improve cognitive function, with a stronger effect on executive function and verbal memory. The treatment is more effective for those with rMDD compared to those with MCI and individuals at low genetic risk for Alzheimer’s disease. The findings were published in JAMA Psychiatry and suggest a potential way to prevent dementia in individuals with a history of depression. The study received support from various organizations.

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