This living systematic review compared interventions for the management of long covid. Moderate certainty evidence suggests that cognitive behavioural therapy (CBT) and physical and mental health rehabilitation are effective, probably reducing fatigue and improving cognitive function, and increasing the proportion of patients experiencing recovery or improvements. Aerobic exercise also probably improves physical function. Other interventions like vortioxetine, leronlimab, and a synbiotic showed no compelling evidence of effectiveness. Concerns were raised about the integrity of some trials. Future studies should replicate promising findings and include patients with different long covid phenotypes. This review will inform future guideline recommendations for long covid management.
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Interventions for the management of long covid (post-covid condition): living systematic review
