Portal vein thrombosis (PVT) is a challenging complication in liver cirrhosis without sensitive diagnostic markers. A study investigated neutrophil extracellular traps (NETs) and Deoxyribonuclease (DNase) as potential indicators for PVT in chronic hepatitis B (CHB)-related decompensated cirrhosis. They found PVT patients had high levels of cell-free DNA and histone-DNA complexes, with reduced DNase activity, regardless of hepatocellular carcinoma (HCC) status. Histone-DNA levels, DNase activity, and hemoglobin were identified as independent risk factors for PVT. High histone-DNA levels showed promise as a diagnostic marker for PVT, with an improved accuracy when combined with other markers. Imbalances in NETs are associated with PVT in CHB-related decompensated cirrhosis, suggesting histone-DNA complexes as a potential diagnostic marker.
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Imbalances in NET homeostasis linked to portal vein thrombosis in CHB-related decompensated cirrhosis
