A new publication in Acta Materia Medica journal explores the efficacy of Herba Siegesbeckiae (HS) in managing cardio- and cerebro-vascular diseases, particularly in ameliorating myocardial ischemia/reperfusion (I/R) injury. The study focuses on the interaction between UCHL5 and NLRP3 in the pathogenesis of I/R and identifies HS-C as the most effective subfraction in protecting against I/R injury. This subfraction significantly inhibits the UCHL5/NLRP3 pathway and contains kirenol as the main active constituent, which accounts for its anti-I/R injury activity. Further research is needed to fully understand the constituents and mechanisms of HS in managing cardiovascular diseases.
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Herba Siegesbeckiae subfraction HS-C protects against myocardial I/R injury
