A recent study found that detection rates for ketamine in drug overdose deaths in the United States increased from 0.3% in 2019 to 0.5% in 2023. Ketamine was identified in less than 1% of drug overdose deaths, with most cases involving illegally manufactured fentanyls, methamphetamine, or cocaine. Data from 228,668 drug overdose deaths across 45 jurisdictions were analyzed, showing ketamine was detected in 0.4% of deaths and involved in 0.2% of deaths. Continued monitoring is needed due to the increase in polysubstance use and ketamine use for treatment-resistant depression. The study was led by Alana M. Vivolo-Kantor and published in Morbidity and Mortality Weekly Report.
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