Scientists have discovered a way to target circular fragments of DNA present in aggressive cancers, opening new treatment possibilities. These extrachromosomal DNA (ecDNA) structures are common in difficult-to-treat cancers like glioblastoma and small cell lung cancer. Researchers found a drug that specifically kills ecDNA-containing cancer cells while sparing normal cells. The study, funded by Cancer Grand Challenges, sheds light on how ecDNA enables tumors to resist treatment. By targeting ecDNA, researchers hope to make aggressive cancers easier to treat. The findings also uncover the impact of ecDNA on cancer evolution and resistance, providing a potential breakthrough in cancer treatment.
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Breakthrough research reveals how to target malignant DNA in aggressive cancers
