Psoriatic arthritis is an inflammatory arthritis affecting 30% of patients with psoriasis. It involves various domains, comorbidities, and extra-musculoskeletal manifestations. Treatment usually starts with NSAIDs and csDMARDs. Biologic and targeted DMARDs are also used, targeting cytokines like TNFα, IL-17, IL-12/23, and IL-23. Non-pharmacologic interventions like education, exercise, and mindfulness are recommended. Clinical assessment tools and outcome measures are crucial for evaluating disease activity. Future research should focus on biomarkers, defining treat-to-target, and managing difficult-to-treat cases. Guidelines from ACR, EULAR, and GRAPPA help in treatment decisions. Unmet needs and emerging treatments enhance the understanding and management of psoriatic arthritis.
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Advances in the management of psoriatic arthritis in adults
