Researchers conducted a study on 4,238 patients with cirrhosis to investigate regional variations in infections and outcomes. They found that 31.9% had confirmed infections at hospital admission, with higher rates in low-income countries. Infections were associated with higher in-hospital death rates. The most common infections were spontaneous bacterial peritonitis, pneumonia, and urinary tract infections. There were significant variations in culture positivity rates and drug resistance, with third-generation cephalosporins being commonly used. Admission infections were linked to increased in-hospital and 30-day mortality, highlighting the need for improved antibiotic use and outcomes in patients with cirrhosis worldwide.
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Variation in cirrhosis infections support streamlined antibiotic use
