A genetic signature in newborns can predict neonatal sepsis before symptoms appear, according to a new study conducted by researchers at UBC, SFU, and MRC Unit The Gambia. Neonatal sepsis, a severe infection in infants, has higher rates in lower- and middle-income countries, leading to significant morbidity and mortality. The study identified four genes that, when combined, could accurately predict sepsis in newborns with a 90 percent success rate. The researchers hope to develop point-of-care devices that can detect this genetic signature to facilitate early diagnosis and treatment, potentially saving lives and reducing the long-term effects of sepsis in infants.
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