Penn Medicine researchers have received an $18 million grant from the NIH/NIA to study cognitive decline in individuals with Lewy body diseases, such as Parkinson’s, and identify biomarkers for predicting dementia. The aim is to understand the factors influencing dementia development and speed, in order to develop therapies to slow disease progression. Research will focus on the role of the protein α-synuclein in Parkinson’s and dementia with Lewy bodies, genetic factors influencing disease progression, and potential gene-editing techniques to regulate α-synuclein spread. Collaboration across projects will help gain a comprehensive understanding of these diseases and develop effective treatments.
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NIH grant supports research on cognitive decline in individuals with Lewy body diseases
