The study explores the role of carnitine transporters in fertility, focusing on the regulation of sperm motility and hormone production to develop new treatments for infertility. Carnitine, crucial in metabolism, is distributed by various membrane transporters across different tissues. Carnitine deficiencies result from genetic mutations in transporters like OCTN2, affecting carnitine reabsorption in the kidneys. Carnitine also plays a role in mitigating oxidative stress, vital for male and female reproductive health. Studies suggest that carnitine supplementation could improve sperm quality and address fertility issues. Understanding the molecular mechanisms of carnitine transporters could pave the way for advanced diagnostic tools and targeted therapies.
Source link