Researchers at Emory University have demonstrated unprecedented control of SIV replication and viral reservoir decay by combining a stringent infection model with the interruption of antiretroviral therapy. This immune-based approach targeted molecules PD1 and IL-10, known to regulate HIV persistence and immune dysfunction. The study, conducted in rhesus macaques highly characterized for SIV infection, showed promising results with nine out of ten monkeys maintaining control of viral rebound for six months after treatment. The research team plans to further understand and develop interventions to induce an immune response capable of long-term control of HIV and SIV without the need for ART.
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Team demonstrates unprecedented control of SIV replication with immune-based approach
