Researchers at the University of Michigan Health Rogel Cancer Center have discovered that the protein NSD2 alters the function of the androgen receptor, leading to rapid cell division and growth that fuels prostate cancer development. This study, published in Nature Genetics, sheds light on how the androgen receptor, which typically regulates normal prostate development, is hijacked in cancer cells. NSD2 is a key collaborator of the androgen receptor that rewires its activity to support prostate cancer development. Targeting NSD2, along with another protein NSD1, could be a potential therapeutic strategy to slow the growth and spread of prostate cancer cells.
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Protein NSD2 found to drive early prostate cancer development
