Researchers found that short-term adoption of low-carbohydrate or low-fat diets does not significantly affect gut-derived appetite hormones compared to pharmacologic treatments or bariatric surgery. A study on 20 adults showed that postprandial concentrations of certain hormones were higher after low-carb meals and lower after low-fat meals. However, no significant correlations were found between hormone responses and subsequent energy intake. Participants on low-carb diets consumed more calories throughout the day compared to those on low-fat diets. The study suggests that dietary macronutrient manipulation may not be as effective in altering energy intake through gut-derived hormones as previously believed.
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