A new research paper published in Aging focused on identifying master regulators of rejuvenation strategies using network biology. Current rejuvenation methods only improve specific cellular processes, with underlying molecular mechanisms largely unknown. Researchers from CIC bioGUNE-BRTA, LCSB, and Ikerbasque developed SINGULAR, a cell rejuvenation atlas providing a comprehensive analysis of different strategies across multiple organs at single-cell resolution. By analyzing six strategies across 73 cell types, they identified master regulators and common targets, particularly in immune cells. SINGULAR could help in selecting drugs that mimic complex interventions and advance human age reversal.
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Cell rejuvenation atlas unveils master regulators of rejuvenation strategies
