A study led by researchers at the UAB Institut de Neurociències shows that daily administration of cannabidiol (CBD) extends lifespan and improves symptoms in animal models of Leigh syndrome, a severe mitochondrial disease in children that has no approved treatments. CBD improves cellular functions and has antioxidant, anti-inflammatory, and anticonvulsant effects. It activates a protein that regulates gene expression involved in immune response and mitochondrial function. Animal models treated with CBD showed improved neuropathology, breathing, and social deficits, as well as delayed motor decline and neurodegenerative signs. CBD has a safe profile and has received orphan drug designation for Leigh syndrome.
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Cannabidiol shown to extend lifespan and improve symptoms in Leigh syndrome models
