Research presented at the EASD 2024 Annual Meeting found that changes in cabin pressure during airplane travel can cause insulin pumps to over-deliver on takeoff and under-deliver on landing. This phenomenon, caused by air bubble formation in the insulin, affects all insulin pumps, including those in hybrid closed-loop systems. Suggestions for mitigating this effect include disconnecting tubing upon takeoff and reconnecting at cruising altitude, or consuming a snack with the Omnipod system. While manufacturers are aware of this issue, the impact on glycemic control is generally minor. Further research is being conducted to understand this phenomenon in people, particularly airline pilots.
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