Memory decline in old age has long been attributed to the loss of dendritic spines in brain neurons. However, a recent study challenges this belief by demonstrating that the quality, rather than the quantity, of synapses in old age plays a crucial role in memory preservation. Researchers found that larger dendritic spine head diameters are associated with better episodic memory performance in older adults. This discovery has significant implications for potential therapies targeting synaptic strength rather than spine generation. The study, conducted with brain samples from elderly individuals, suggests that maintaining or enhancing synaptic strength could improve memory in aging and Alzheimer’s disease dementia.
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Research finds synaptic strength key to maintaining memory in old age
