Researchers at Cincinnati Children’s have identified a new molecular signaling pathway involving the protein CARD14 that is crucial for maintaining the skin barrier, which could lead to new treatments for inflammatory skin diseases like eczema and psoriasis. The study, published in Cell Reports, found that when CARD14 interacts with MYC, a protein that controls cell growth, it helps protect against skin diseases. The study also suggests that dysfunctional CARD14-MYC signaling could contribute to various types of cancer. The team is now looking for small-molecule agents that can affect this pathway to develop novel therapeutics and will present their findings at a conference in 2025.
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Novel molecular signaling pathway found to play a crucial role in maintaining the skin barrier
