Intensive glucose control in critically ill adults does not reduce mortality risk compared to conventional glucose control but increases the risk of severe hypoglycemia. A new meta-analysis found that intensive glucose control did not decrease mortality but tripled the risk of severe hypoglycemia. Previous research on intensive insulin therapy targeting normoglycemia has yielded conflicting results. Current guidelines recommend insulin therapy only for hyperglycemia ≥180 mg/dL on two occasions. The study analyzed individual patient data from randomized controlled trials in critically ill adults to assess the impact on mortality. Researchers advised clinicians to target glucose levels at 140-180 mg/dL in critically ill patients to prevent hypoglycemia. The study was funded by various health organizations and the lead author disclosed no relevant financial relationships.
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No Benefit of Intensive Glucose Control in Critical Patients
