A study published in Clinical Gastroenterology and Hepatology found distinct microbial signatures in mucosa-associated microbiota from ileal and colonic specimens that predict Crohn’s disease recurrence after surgery. Researchers analyzed biopsy samples from 262 patients with Crohn’s disease, finding lower diversity and specific microbial changes in patients who developed recurrence. By including microbiome data, the prediction of recurrence risk improved compared to clinical data alone. The study suggests that assessing microbial biomarkers in rectosigmoid mucosa could help predict recurrence. Limitations include a small sample size and lack of central reading for endoscopy scores. The study was supported by the NIH with no conflicts of interest declared by the authors.
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Gut Flora Predicts Postoperative Crohn’s Disease Recurrence
