Brain circuits connecting stress to gut bacteria reveal new pathways for immune regulation

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A recent study published in Cell revealed that stress-sensitive neural circuits can alter the gut microbiome by influencing duodenal glands. The study showed that the brain’s impact on mucosal secretion plays a key role in regulating the gut microbiome, particularly by promoting the growth of beneficial bacteria like Lactobacilli. The researchers found that stress-induced changes in brain activity led to reduced mucus secretion, impacting microbial growth and immune function in the gut. Additionally, probiotic administration was found to counteract these effects, highlighting the potential for interventions to mitigate stress-related disruptions in gut health. The study provides insights into the complex interplay between brain states and gut microbiome dynamics.

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