Dr Ray O’Connor examined recent clinical studies on lupus and discussed systemic lupus erythematosus (SLE), a severe autoimmune disease affecting multiple body systems. SLE is complex and unpredictable, with flares and remissions. It predominantly affects women, with a female to male ratio of 9:1. The global epidemiology of SLE varies by sex, age, and region. Diagnosis and management involve a combination of clinical factors and immunologic measures. Treatment aims to achieve remission with medication, including hydroxychloroquine and immunosuppressive agents. Pregnant women with SLE are at risk of adverse outcomes, but multidisciplinary management can lead to healthier pregnancies. Recent FDA-approved treatments for SLE include belimumab, voclosporin, and anifrolumab.
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