Brain inflammation in infections and neurodegenerative diseases can lead to muscle problems, independent of the nervous system. Researchers at Washington University School of Medicine discovered that a specific protein released during brain inflammation travels to the muscles, causing a loss of function. By studying fruit flies and mice, they found that inflammatory proteins from the brain reduce energy levels in muscles, affecting movement. This process is relevant in diseases like bacterial infections, Alzheimer’s, and COVID-19. Identified pathways could be targeted with existing treatments to prevent muscle weakness. Further research is needed to understand the impact of this brain-muscle signaling axis on overall health.
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Study reveals how inflammation weakens muscles during illness
