The misuse of the veterinary tranquilizer xylazine, often mixed with fentanyl, is on the rise in the United States. This combination poses a significant challenge as it often does not respond to naloxone, can cause severe skin wounds, and has led to necrotic lesions. Reports from Millennium Health show an increase in positive urine tests for xylazine, particularly in the western US. Despite efforts by the FDA and DEA to curb trafficking, xylazine use continues to spread across the country. Clinicians are urged to be mindful of the risks associated with xylazine use, especially in conjunction with fentanyl.
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‘Emerging Threat’ Xylazine Use Continues to Spread in the US
