Researchers in Finland have discovered that the TIMP-1 protein, known for tissue protection, is crucial for the immune system’s ability to combat cancer. The protein produced by dendritic cells boosts antitumor immunity by activating immune cells. Enhancing TIMP-1 expression or targeting its inhibitors in tumors with weak immune responses could improve cancer immunotherapies. This discovery may also aid in fighting infections. The study used patient samples and advanced tools for a molecular understanding of cancer immunity. The findings, published in Genes & Immunity, highlight a reverse translational approach that starts with real-world patient data to guide laboratory studies.
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TIMP-1 protein found to boost immune system’s fight against cancer
