A recent study published in Nature Human Behaviour investigated the role of specific oscillatory activity patterns in the human striatum in reinforcement motor learning using transcranial temporal interference stimulation (tTIS) with neuroimaging. The study involved 48 healthy volunteers who performed a force-tracking task with tTIS of the striatum during training. Results showed that tTIS disrupted reinforcement benefits on motor learning, with tTIS80Hz impairing performance. Higher gamma striatal tTIS disrupted reinforcement benefits, modulating striatal neural activity and connectivity with frontal cortical areas. These findings suggest that tTIS can non-invasively modulate striatal mechanisms in reinforcement learning, providing insights into deep brain structures and behavior.
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The role of striatal oscillatory activity explored
