Researchers found that bile duct dysplasia or cholangiocarcinoma was present in most explanted livers in patients with primary sclerosing cholangitis. However, 41% of patients with this indication had no signs of neoplasia. The practice of preemptive liver transplantation in patients with bile duct dysplasia is common in the Nordic countries to prevent the development of cholangiocarcinoma, but remains controversial due to organ supply concerns. Evaluating data from the Nordic Liver Transplant Registry, researchers found that low-grade dysplasia and high-grade dysplasia were associated with less advanced liver disease, while other indications were associated with cirrhosis. Their findings suggest the need to improve criteria for selecting candidates for liver transplantation.
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‘Substantial proportion’ of PSC patients listed for LT due to dysplasia have no neoplasia
