A recent study found that transferring immunoglobulin G (IgG) from long COVID patients to mice causes symptoms, suggesting a link between autoimmunity and long COVID. The study included 34 long COVID patients and 15 controls with mild infections. Patients exhibited diverse symptoms, with fatigue being a common factor. The study identified three distinct long COVID subgroups based on cytokine levels. IgG transfer induced pain-related behaviors and reduced locomotor activity in mice, indicating a potential role of IgG in long COVID pathogenesis. Further research is needed to identify specific pathogenic IgGs for targeted therapies.
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IgG from long COVID patients induces specific symptoms in mice, confirming autoimmunity’s role
