Higher initial doses of glucocorticoids improve renal outcomes in patients with lupus nephritis, but also increase the risks of serious infections and mortality. A study conducted a meta-analysis of 37 randomized controlled trials with 3,231 patients to evaluate the impact of glucocorticoid regimens. Starting at 60 mg per day of prednisone without pulses resulted in a higher complete response rate at 6 months, but also increased the risk of serious infections and death compared to starting at 25 mg per day. The study highlights the trade-offs of using glucocorticoids in lupus nephritis treatment and provides important information for clinical decision-making.
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Higher steroid dose improves lupus nephritis renal outcomes, raises mortality risk
