A study published in The Lancet Psychiatry found that one in three people who stop taking antidepressants experience discontinuation symptoms, while one in six people who discontinue a placebo also experience symptoms. The study included 79 studies with 21,002 patients who discontinued antidepressants or placebo. Certain medications, such as imipramine, paroxetine, and desvenlafaxine or venlafaxine, had higher rates of severe discontinuation symptoms. The research suggests that only half of the symptoms can be attributed to the medication, and most patients can discontinue antidepressants without significant symptoms. The study highlights the importance of understanding and managing antidepressant discontinuation symptoms.
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15% of patients experience antidepressant discontinuation symptoms, which are mostly mild
