Experts are discussing the potential for anti-obesity drugs to contribute to the loss of lean mass, which is necessary to maintain metabolic function. While lean mass loss is expected with successful weight loss interventions, measures should be recommended to prevent these effects. Significant fat loss from anti-obesity medications can outweigh the drawbacks of lean mass loss, as it has been linked to various health benefits. Clinicians should educate patients on the importance of strength training and nutrition to offset lean mass loss. Older patients are particularly vulnerable to lean mass loss and may require special considerations. Overall, lean mass loss can be reversed with effort and proper nutrition.
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