Study finds accounting for sex improves precision and prognostic performance of CMR biomarkers for heart failure

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A recent study in the European Heart Journal Open focused on the impact of sex on cardiac magnetic resonance (CMR) assessment of left ventricular filling pressure (LVFP) in heart failure (HF) diagnosis. The study highlighted the need for gender-specific diagnostic and treatment approaches in heart disease, particularly in women. The research identified sex-specific differences in CMR-derived PCWP values and developed a sex-specific CMR-derived PCWP equation that improved prognostic performance. The study found that the sex-specific model was independently associated with major adverse cardiovascular events (MACE) and provided more accurate predictions compared to generic CMR-derived models. The findings suggest that incorporating sex-specific factors in cardiac imaging can enhance the diagnosis and treatment of heart failure in women.

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