Proteinuria levels do not predict the type of lupus nephritis, requiring separate study approaches. Distinct serological profiles between membranous lupus nephritis (MLN) and proliferative lupus nephritis (PLN) indicate differing pathogenesis. A retrospective analysis of 260 patients with lupus nephritis showed no difference in proteinuria levels between MLN and PLN, but significant variations in serum creatinine and anti-dsDNA positivity. The strongest predictor of progression to chronic kidney disease was a glomerular filtration rate of 75 mL/minute/1.73 m2 or less at 1 year. Researchers recommend monitoring patients closely and using treatment strategies to improve outcomes for both conditions.
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Serology ‘significantly different’ between membranous vs. proliferative lupus nephritis
