Personalized repetitive transcranial magnetic stimulation (rTMS) targeting the hippocampal network showed promise in improving cognitive and functional performance in patients with early Alzheimer’s disease. The study, published in JAMA Network Open, used personalized fMRI analysis to guide stimulation at the optimal target site. Results showed significant improvements in memory and daily living activities in the rTMS group compared to sham treatment. Additionally, increased functional connectivity between the hippocampus and precuneus was associated with improvements in cognitive scores. The researchers suggest that rTMS could be a potential nonpharmacological treatment for Alzheimer’s disease, supported by their findings.
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Personalized rTMS Promising for Early Alzheimer’s
