In a study led by Prof. Itamar Harel, researchers found a novel link between germline regulation and the balance of longevity and somatic repair in vertebrates. The research challenges traditional beliefs that reproduction and lifespan are linked by limited resources. By studying turquoise killifish, the team discovered that removing the germline has different effects on males and females, with males experiencing extended lifespan and females showing improved ability to repair damage. The study also identified genes and pathways related to longer life and rejuvenated metabolic functions in males. This research opens new possibilities for understanding aging mechanisms in vertebrates.
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How they impact lifespan in vertebrates
