A team of experts in MS research recommends a structured approach to studying mechanisms of exercise training for improving outcomes in multiple sclerosis. They emphasize the value of an experimental medicine framework to optimize exercise interventions in MS rehabilitation. While pharmacological treatments can prevent relapses, they do not improve functions affected by the disease. Exercise training can potentially improve neurological symptoms of MS. The experts review the current literature and propose a framework with four main steps to integrate exercise training into MS rehabilitation protocols. By understanding how exercise affects the CNS in MS, interventions can be designed to enhance mobility, cognition, and quality of life.
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