A study led by Stanford Medicine reveals that two key brain systems are dysfunctional in individuals with psychosis: a “filter” that directs attention and a “predictor” linked to anticipating rewards. This dysfunction causes difficulties in distinguishing reality, leading to hallucinations and delusions. The study, published in Molecular Psychiatry, used brain scan data from people with psychosis and confirmed existing theories about breaks with reality. The findings can help understand the development and progression of schizophrenia. Researchers aim to use these findings for early intervention and potential prevention of psychosis, as well as monitoring the effectiveness of existing treatments using functional MRI.
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Two key brain systems are central to psychosis, study finds
