Two systematic reviews found that evidence on the use of puberty blockers and hormones for children and young people with gender-related distress is inadequate, leading to uncertainty about their effectiveness and impact on health. The studies showed limited quality and inconsistent evidence on key outcomes. Clinical guidelines are often not evidence-based, and the need for psychosocial support lacks consensus. Dr. Hilary Cass emphasized the need for a holistic assessment by a multi-professional team to support gender-questioning youth. Lack of evidence in gender medicine led to a call for more research and standardized care delivery. The reviews revealed a gap in meeting the health and wellbeing needs of gender-questioning children and young people.
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Systematic reviews find inadequate evidence on the use of puberty blockers and hormones for gender distress
