Research highlights STON2 variations involved in synaptic dysfunction and schizophrenia-like behaviors

The study focused on STON2 variations related to synaptic dysfunction and schizophrenia-like behaviors. The C-C (307Pro-851Ala) haplotype of STON2 was found to increase susceptibility to schizophrenia in the Chinese Han population. This variation leads to deficits in synaptic transmission, short-term plasticity, and schizophrenia-like behaviors in mice. Pharmacogenomic data showed that patients with this haplotype responded better to haloperidol, which restored schizophrenia-related behaviors in mice by regulating synaptotagmin 1 sorting and synaptic transmission. The findings highlight the potential of targeting STON2 variations for treating schizophrenia-like symptoms. The research was led by Prof. Jun Li, Prof. Dai Zhang, Dr. Yuanlin Ma, and Dr. Kai Gao.

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